Immunopathogenesis of hepatitis B virus infection

Ju-Hui Judy Chang, Sharon R Lewin

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)


Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.
Original languageEnglish
Pages (from-to)16 - 23
Number of pages8
JournalImmunology and Cell Biology
Issue number1
Publication statusPublished - 2007

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