TY - JOUR
T1 - Immunopathogenesis of granulomas in chronic autoinflammatory diseases
AU - Timmermans, Wilhelmina Maria Cornelia
AU - Van Laar, Jan Alexander Michael
AU - Van Hagen, Petrus Martinus
AU - van Zelm, Menno Cornelis
PY - 2016
Y1 - 2016
N2 - Granulomas are clusters of immune cells. These structures can be formed in reaction to infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several immune disorders, such as sarcoidosis, Crohn's disease and common variable immunodeficiency, non-caseating granulomas are formed without an obvious infectious trigger. Despite advances in our understanding of the human immune system, the pathogenesis underlying these non-caseating granulomas in chronic inflammatory diseases is still poorly understood. Here, we review the current knowledge about the immunopathogenesis of granulomas, and we discuss how the involved immune cells can be targeted with novel therapeutics.
AB - Granulomas are clusters of immune cells. These structures can be formed in reaction to infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several immune disorders, such as sarcoidosis, Crohn's disease and common variable immunodeficiency, non-caseating granulomas are formed without an obvious infectious trigger. Despite advances in our understanding of the human immune system, the pathogenesis underlying these non-caseating granulomas in chronic inflammatory diseases is still poorly understood. Here, we review the current knowledge about the immunopathogenesis of granulomas, and we discuss how the involved immune cells can be targeted with novel therapeutics.
U2 - 10.1038/cti.2016.75
DO - 10.1038/cti.2016.75
M3 - Review Article
SN - 2050-0068
VL - 5
JO - Clinical & Translational Immunology
JF - Clinical & Translational Immunology
M1 - e118
ER -
