Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis

Ian R. Van Driel, Alan G. Baxter, Karen L. Laurie, Tricia D. Zwar, Nicole L. La Gruta, Louise M. Judd, Katrina L. Scarff, Pablo A. Silveira, Paul A. Gleeson

Research output: Contribution to journalReview ArticleResearchpeer-review

34 Citations (Scopus)

Abstract

Over the past 10 years experimental autoimmune gastritis has been established as a highly defined model of organ-specific autoimmunity. Autoimmune gastritis represents one of the few autoimmune diseases in which the causative autoantigens, namely the gastric H/K ATPase α- and β-subunits, are defined. Furthermore, it has been clearly established that a CD4+ T cell response to the H/K ATPase β-subunit, in particular, is essential for the initiation of autoimmune gastritis. The immunopathology of autoimmune gastritis is due to a disruption of the normal developmental pathways of the mucosa, rather than a direct depletion of the end-stage parietal and zymogenic cells. CD4+CD25+ regulatory T cells were first described in experimental autoimmune gastritis and there has been a recent explosion of interest in the potential role of these immunoregulatory T cells in protection against a variety of autoimmune diseases. The availability of H/K ATPase deficient mice has begun to provide considerable insight into the basis for tolerance to the gastric autoantigens. Experimental autoimmune gastritis has also provided valuable insight into our understanding of the genetics of disease susceptibility and four distinct genetic regions have been identified which confer susceptibility to this organ-specific disease. The highlights of these recent advances are the subject of this review.

Original languageEnglish
Pages (from-to)290-297
Number of pages8
JournalAutoimmunity Reviews
Volume1
Issue number5
DOIs
Publication statusPublished - 1 Oct 2002

Keywords

  • Autoimmune gastritis
  • CD25CD4 T cells, T cell tolerance.
  • Gastric H/K ATPase
  • H/K ATPase α-subunit, H/Kα
  • H/K ATPase β-subunit, H/Kβ.

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