Mesenchymal stem cells (MSCs) are an important cell population that resides in a bone marrow microenvironment. In the past decade, MSCs have been discovered to have profound immunomodulatory functions both in vitro and in vivo. As MSCs can be expanded rapidly to numbers that are required for clinical application, clinical studies have been performed in immune diseases, bone marrow transplantation and kidney transplantation. In this chapter, the mechanisms underlying MSCs' immunomodulating property and the potential clinical use of MSCs as a modulator of immune responses are reviewed.
|Title of host publication||Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation|
|Number of pages||16|
|Publication status||Published - 1 Jan 2013|
- Antigen-presenting cells
- Immunomodulatory functions
- T cells