Immunomodulatory properties of mesenchymal stem cells and related applications

Lianming Liao, Robert Chunhua Zhao

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Mesenchymal stem cells (MSCs) are an important cell population that resides in a bone marrow microenvironment. In the past decade, MSCs have been discovered to have profound immunomodulatory functions both in vitro and in vivo. As MSCs can be expanded rapidly to numbers that are required for clinical application, clinical studies have been performed in immune diseases, bone marrow transplantation and kidney transplantation. In this chapter, the mechanisms underlying MSCs' immunomodulating property and the potential clinical use of MSCs as a modulator of immune responses are reviewed.

Original languageEnglish
Title of host publicationEssentials of Mesenchymal Stem Cell Biology and Its Clinical Translation
Number of pages16
ISBN (Electronic)9789400767164
ISBN (Print)9789400767157
Publication statusPublished - 1 Jan 2013
Externally publishedYes


  • Antigen-presenting cells
  • Immunomodulatory functions
  • Interactions
  • MSC
  • T cells

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