Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice

Ling Zhang; Ting Jun Hu; Chun Ni Lu

doi:10.5897/ajb11.948

Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice

Ling Zhang, Ting Jun Hu, Chun Ni Lu

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

The aim of this present study was to investigate the immunomodulatory and antioxidant activities of Siraitia grosvenorii polysaccharide (SGP) using a mouse model. The roles of regulation of SGP were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescence method and ELISA method. The chemical structures were analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography (GC). The results show that SGP promoted the proliferation of spleen cells and regulated the level of reactive oxygen species (ROS) in vitro. Furthermore, it significantly raised spleen and thymus indices and superoxidase dismutase activity and regulated the cytokine levels of spleen and thymus in mice in vivo. These findings suggest that SGP possesses immunomodulatory and antioxidant effects.

Original language	English
Pages (from-to)	10045-10053
Number of pages	9
Journal	African Journal of Biotechnology
Volume	10
Issue number	49
DOIs	https://doi.org/10.5897/ajb11.948
Publication status	Published - 31 Aug 2011
Externally published	Yes

Keywords

Cell proliferation
Cytokines
Reactive oxygen species
Siraitia grosvenorii polysaccharide (SGP)
Superoxidase dismutase

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10.5897/ajb11.948

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title = "Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice",

abstract = "The aim of this present study was to investigate the immunomodulatory and antioxidant activities of Siraitia grosvenorii polysaccharide (SGP) using a mouse model. The roles of regulation of SGP were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescence method and ELISA method. The chemical structures were analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography (GC). The results show that SGP promoted the proliferation of spleen cells and regulated the level of reactive oxygen species (ROS) in vitro. Furthermore, it significantly raised spleen and thymus indices and superoxidase dismutase activity and regulated the cytokine levels of spleen and thymus in mice in vivo. These findings suggest that SGP possesses immunomodulatory and antioxidant effects.",

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doi = "10.5897/ajb11.948",

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AU - Zhang, Ling

AU - Hu, Ting Jun

AU - Lu, Chun Ni

PY - 2011/8/31

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N2 - The aim of this present study was to investigate the immunomodulatory and antioxidant activities of Siraitia grosvenorii polysaccharide (SGP) using a mouse model. The roles of regulation of SGP were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescence method and ELISA method. The chemical structures were analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography (GC). The results show that SGP promoted the proliferation of spleen cells and regulated the level of reactive oxygen species (ROS) in vitro. Furthermore, it significantly raised spleen and thymus indices and superoxidase dismutase activity and regulated the cytokine levels of spleen and thymus in mice in vivo. These findings suggest that SGP possesses immunomodulatory and antioxidant effects.

AB - The aim of this present study was to investigate the immunomodulatory and antioxidant activities of Siraitia grosvenorii polysaccharide (SGP) using a mouse model. The roles of regulation of SGP were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescence method and ELISA method. The chemical structures were analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography (GC). The results show that SGP promoted the proliferation of spleen cells and regulated the level of reactive oxygen species (ROS) in vitro. Furthermore, it significantly raised spleen and thymus indices and superoxidase dismutase activity and regulated the cytokine levels of spleen and thymus in mice in vivo. These findings suggest that SGP possesses immunomodulatory and antioxidant effects.

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KW - Reactive oxygen species

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Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice

Abstract

Keywords

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