TY - JOUR
T1 - Immunology
T2 - Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
AU - Maeda, Takahiro
AU - Merghoyb, Taha
AU - Hobbs, Robin M.
AU - Dong, Lin
AU - Maeda, Manami
AU - Zakrzewski, Johannes
AU - Van Den Brink, Marcel R.M.
AU - Zelent, Arthur
AU - Shigematsu, Hirokazu
AU - Akashi, Koichi
AU - Teruya-Feldstein, Julie
AU - Cattoretti, Giorgio
AU - Pandolfi, Pier Paolo
PY - 2007/5/11
Y1 - 2007/5/11
N2 - Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
AB - Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
UR - http://www.scopus.com/inward/record.url?scp=34248580502&partnerID=8YFLogxK
U2 - 10.1126/science.1140881
DO - 10.1126/science.1140881
M3 - Article
C2 - 17495164
AN - SCOPUS:34248580502
SN - 0036-8075
VL - 316
SP - 860
EP - 866
JO - Science
JF - Science
IS - 5826
ER -