Immunologically privileged environments

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    Abstract

    The term “immunological privilege” has been used to describe tissues that were believed to be inaccessible to circulating immune cells, due to the existence of blood-tissue “barriers” and/or deficient lymphatic drainage to local lymph nodes. In this chapter the terms “immunological privilege” and “immunoprivilege” are used to refer to the extended survival of cells expressing antigens that under normal circumstances should provoke an immune response, as well as to the mechanisms that contribute to this survival. The better-known and studied organs that display immunological privilege include the eye, the brain, the testes, and the pregnant uterus, and placenta. Less well known is the fact that immunological privilege also has been attributed to subcutaneous fatty tissue, the hair follicle matrix, the prostate, the adrenal gland, the liver, and even the bone marrow space and scar tissue. One of the most obvious potential benefits from understanding the principles of immunoregulation that operate in immunologically privileged sites such as the testis is the possibility that the same mechanisms might be used to control immune responses at other sites too.

    Original languageEnglish
    Title of host publicationCellular Transplantation
    Subtitle of host publicationFrom Laboratory to Clinic
    EditorsCraig Halberstadt, Dwaine Emerich
    Place of PublicationCalifornia USA
    PublisherElsevier
    Chapter30
    Pages567-590
    Number of pages24
    ISBN (Electronic)9780123694157
    ISBN (Print)9780080469041
    DOIs
    Publication statusPublished - 2007

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