Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis

Yasuhiro Miki; Colin D. Clyne; Takashi Suzuki; Takuya Moriya; Rie Shibuya; Yasuhiro Nakamura; Takanori Ishida; Nami Yabuki; Kunio Kitada; Shin ichi Hayashi; Hironobu Sasano

doi:10.1016/j.canlet.2005.11.038

Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis

Yasuhiro Miki, Colin D. Clyne, Takashi Suzuki, Takuya Moriya, Rie Shibuya, Yasuhiro Nakamura, Takanori Ishida, Nami Yabuki, Kunio Kitada, Shin ichi Hayashi, Hironobu Sasano

Research output: Contribution to journal › Article › Research › peer-review

44 Citations (Scopus)

Abstract

Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.

Original language	English
Pages (from-to)	24-33
Number of pages	10
Journal	Cancer Letters
Volume	244
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.11.038
Publication status	Published - 28 Nov 2006
Externally published	Yes

Keywords

Breast cancer
LRH-1
Steroidogenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2005.11.038

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title = "Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis",

abstract = "Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.",

keywords = "Breast cancer, LRH-1, Steroidogenesis",

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T1 - Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma

T2 - Possible regulator of in situ steroidogenesis

AU - Miki, Yasuhiro

AU - Clyne, Colin D.

AU - Suzuki, Takashi

AU - Moriya, Takuya

AU - Shibuya, Rie

AU - Nakamura, Yasuhiro

AU - Ishida, Takanori

AU - Yabuki, Nami

AU - Kitada, Kunio

AU - Hayashi, Shin ichi

AU - Sasano, Hironobu

PY - 2006/11/28

Y1 - 2006/11/28

N2 - Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.

AB - Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.

KW - Breast cancer

KW - LRH-1

KW - Steroidogenesis

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VL - 244

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis

Abstract

Keywords

UN SDGs

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