Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of in situ steroidogenesis

Yasuhiro Miki, Colin D. Clyne, Takashi Suzuki, Takuya Moriya, Rie Shibuya, Yasuhiro Nakamura, Takanori Ishida, Nami Yabuki, Kunio Kitada, Shin ichi Hayashi, Hironobu Sasano

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)


Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalCancer Letters
Issue number1
Publication statusPublished - 28 Nov 2006
Externally publishedYes


  • Breast cancer
  • LRH-1
  • Steroidogenesis

Cite this