Immunohistochemical localization of parathyroid hormone‐related protein in parathyroid adenoma and hyperplasia

Janine A. Danks, Peter R. Ebeling, John A. Hayman, Hannelore Diefenbach‐jagger, Fiona Mcl Collier, Vivian Grill, Justine Southby, Jane M. Moseley, S. T. Chou, T. John Martin

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Abstract

Parathyroid hormone‐related protein (PTHrP) is invoked as the cause of humoral hypercalcaemia of malignancy (HHM); it is contained in the keratinocyte layer of normal skin; and there is evidence that is is produced by fetal parathyroids. Antibodies against synthetic PTHrP peptides have been raised in rabbits and sheep. This immunohisto‐chemical study has found that primary parathyroid adenomata and hyperplastic glands from patients with chronic renal failure stain positively with antisera against PTHrP(1–34) and PTHrP(50–69). Primary hyperplastic glands are negative. No staining with anti‐PTHrP(106–141) antiserum could be detected immunohistochemically in any of the parathyroid adenomata or hyperplasia.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalJournal of Pathology
Volume161
Issue number1
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Keywords

  • Hypercalcaemia
  • hyperparathyroidism
  • parathyroid adenomata
  • parathyroid hyperplasia

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