Immunoglobulin-G4 related mastitis: A case report

Ee Syn Tan, Brendon Friesen, Seow Foong Loh, Jane Fox

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Introduction IgG4-related mastitis (IgG4-RM) is exceedingly rare with only ten cases reported in the literature to date. Organs that are affected with IgG4-related disease (IgG4-RD) all share the same histopathological hallmarks consisting of dense lymphocytic infiltration, storiform fibrosis and obliterative phlebitis. Presentation of case This case report highlights a case of IgG4-RM found incidentally in a 52-year-old woman during a routine breast screen and it explores the current literature about IgG4-RM and IgG4-RD. Discussion IgG4-RM and IgG4-RD, in general, is a new entity in the field of medicine and its aetiology is not well understood. In the literature, IgG4-RM often presents as a painless palpable breast lump in isolation or with other systemic manifestations. IgG4-RM is considered benign and has excellent prognosis post-conservative treatment with steroid or surgical excision. Conclusion IgG4-RM is diagnosed exclusively on histological analysis. It is hard to distinguish IgG4-RD from malignant breast lesions purely on clinical examination and imaging studies. Increasing awareness of this condition among clinicians will assist them in managing patients better. Extensive whole body imaging is not recommended unless symptomatic.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalInternational Journal of Surgery Case Reports
Volume37
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Autoimmune
  • Breast
  • Case report
  • Granulomatous disease
  • Immunoglobulin-G4
  • Sclerosing mastitis

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