TY - JOUR
T1 - Immunogenicity and immunological priming of the serogroup A portion of a bivalent meningococcal A/C conjugate vaccine in 2-year-old children
AU - Joseph, Helen
AU - Ryall, Robert
AU - Bybel, Mike
AU - Papa, Thomas
AU - MacLennan, Jenny
AU - Buttery, Jim
AU - Borrow, Raymond
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels.
AB - Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels.
UR - http://www.scopus.com/inward/record.url?scp=0344407012&partnerID=8YFLogxK
U2 - 10.1086/368358
DO - 10.1086/368358
M3 - Article
C2 - 12660929
AN - SCOPUS:0344407012
SN - 0022-1899
VL - 187
SP - 1142
EP - 1146
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 7
ER -
