Abstract
T-cell regulation by CD52-expressing CD4 T cells appears to operate by two different and possibly synergistic mechanisms. The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70. The second mechanism appears to be by crosslinkage of the CD52 molecules by an as yet unidentified endogenous ligand that is mimicked by a bivalent anti-CD52 antibody that results in their expansion.
Original language | English |
---|---|
Pages (from-to) | 379 - 382 |
Number of pages | 4 |
Journal | Cellular & Molecular Immunology |
Volume | 10 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2013 |