Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

Hassan M. Rostam; Leanne E. Fisher; Andrew L. Hook; Laurence Burroughs; Jeni C. Luckett; Grazziela P. Figueredo; Chidimma Mbadugha; Alvin C.K. Teo; Arsalan Latif; Lisa Kämmerling; Mitchell Day; Karen Lawler; David Barrett; Somaia Elsheikh; Mohammad Ilyas; David A. Winkler; Morgan R. Alexander; Amir M. Ghaemmaghami

doi:10.1016/j.matt.2020.03.018

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

Hassan M. Rostam, Leanne E. Fisher, Andrew L. Hook, Laurence Burroughs, Jeni C. Luckett, Grazziela P. Figueredo, Chidimma Mbadugha, Alvin C.K. Teo, Arsalan Latif, Lisa Kämmerling, Mitchell Day, Karen Lawler, David Barrett, Somaia Elsheikh, Mohammad Ilyas, David A. Winkler, Morgan R. Alexander, Amir M. Ghaemmaghami

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive properties of these materials are validated within a rodent model. By identifying novel materials with immune-instructive properties, the relationship between material-immune cell interactions could be investigated, and this offers exciting possibilities to design novel bioinstructive materials that can be used for numerous clinical applications including medical implants.

Original language	English
Pages (from-to)	1564-1581
Number of pages	19
Journal	Matter
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.matt.2020.03.018
Publication status	Published - 3 Jun 2020

Keywords

bioinstructive materials
high-throughput polymer screening
immune modulation
machine learning
macrophage
MAP2: Benchmark
regenerative medicine

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10.1016/j.matt.2020.03.018

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https://www.sciencedirect.com/science/article/pii/S2590238520301314

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Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., Mbadugha, C., Teo, A. C. K., Latif, A., Kämmerling, L., Day, M., Lawler, K., Barrett, D., Elsheikh, S., Ilyas, M., Winkler, D. A., Alexander, M. R., & Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

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abstract = "Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive properties of these materials are validated within a rodent model. By identifying novel materials with immune-instructive properties, the relationship between material-immune cell interactions could be investigated, and this offers exciting possibilities to design novel bioinstructive materials that can be used for numerous clinical applications including medical implants.",

keywords = "bioinstructive materials, high-throughput polymer screening, immune modulation, machine learning, macrophage, MAP2: Benchmark, regenerative medicine",

author = "Rostam, {Hassan M.} and Fisher, {Leanne E.} and Hook, {Andrew L.} and Laurence Burroughs and Luckett, {Jeni C.} and Figueredo, {Grazziela P.} and Chidimma Mbadugha and Teo, {Alvin C.K.} and Arsalan Latif and Lisa K{\"a}mmerling and Mitchell Day and Karen Lawler and David Barrett and Somaia Elsheikh and Mohammad Ilyas and Winkler, {David A.} and Alexander, {Morgan R.} and Ghaemmaghami, {Amir M.}",

year = "2020",

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doi = "10.1016/j.matt.2020.03.018",

language = "English",

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Rostam, HM, Fisher, LE, Hook, AL, Burroughs, L, Luckett, JC, Figueredo, GP, Mbadugha, C, Teo, ACK, Latif, A, Kämmerling, L, Day, M, Lawler, K, Barrett, D, Elsheikh, S, Ilyas, M, Winkler, DA, Alexander, MR & Ghaemmaghami, AM 2020, 'Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo', Matter, vol. 2, no. 6, pp. 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

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AU - Rostam, Hassan M.

AU - Fisher, Leanne E.

AU - Hook, Andrew L.

AU - Burroughs, Laurence

AU - Luckett, Jeni C.

AU - Figueredo, Grazziela P.

AU - Mbadugha, Chidimma

AU - Teo, Alvin C.K.

AU - Latif, Arsalan

AU - Kämmerling, Lisa

AU - Day, Mitchell

AU - Lawler, Karen

AU - Barrett, David

AU - Elsheikh, Somaia

AU - Ilyas, Mohammad

AU - Winkler, David A.

AU - Alexander, Morgan R.

AU - Ghaemmaghami, Amir M.

PY - 2020/6/3

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KW - high-throughput polymer screening

KW - immune modulation

KW - machine learning

KW - macrophage

KW - MAP2: Benchmark

KW - regenerative medicine

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JO - Matter

JF - Matter

SN - 2590-2393

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ER -

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

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Keywords

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