Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

Hassan M. Rostam, Leanne E. Fisher, Andrew L. Hook, Laurence Burroughs, Jeni C. Luckett, Grazziela P. Figueredo, Chidimma Mbadugha, Alvin C.K. Teo, Arsalan Latif, Lisa Kämmerling, Mitchell Day, Karen Lawler, David Barrett, Somaia Elsheikh, Mohammad Ilyas, David A. Winkler, Morgan R. Alexander, Amir M. Ghaemmaghami

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive properties of these materials are validated within a rodent model. By identifying novel materials with immune-instructive properties, the relationship between material-immune cell interactions could be investigated, and this offers exciting possibilities to design novel bioinstructive materials that can be used for numerous clinical applications including medical implants.

Original languageEnglish
Pages (from-to)1564-1581
Number of pages19
JournalMatter
Volume2
Issue number6
DOIs
Publication statusPublished - 3 Jun 2020

Keywords

  • bioinstructive materials
  • high-throughput polymer screening
  • immune modulation
  • machine learning
  • macrophage
  • MAP2: Benchmark
  • regenerative medicine

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