TY - JOUR
T1 - Immune Function After Splenic Artery Embolization for Blunt Trauma
T2 - Long-Term Assessment of CD27+ IgM B-Cell Levels
AU - Lukies, Matthew
AU - Zia, Adil
AU - Kavnoudias, Helen
AU - Bosco, Julian J.
AU - Narita, Callum
AU - Lee, Robin
AU - Joseph, Timothy
AU - Clements, Warren
N1 - Funding Information:
Funding for this study was provided via a competitive funding grant from the Royal Australian and New Zealand College of Radiologists .
Publisher Copyright:
© 2022 SIR
PY - 2022/5
Y1 - 2022/5
N2 - Splenic artery embolization (SAE) plays a critical role in the treatment of high-grade splenic injury not requiring emergent laparotomy. SAE preserves splenic tissue, and growing evidence demonstrates preserved short-term splenic immune function after SAE. However, long-term function is less studied. Patients who underwent SAE for blunt abdominal trauma over a 10-year period were contacted for long-term follow-up. Sixteen participants (sex: women, 10, and men, 6; age: median, 34 years, and range, 18–67 years) were followed up at a median of 7.7 years (range, 4.7–12.8 years) after embolization. Splenic lacerations were of American Association for the Surgery of Trauma grades III to V, and 14 procedures involved proximal embolization. All individuals had measurable levels of IgM memory B cells (median, 14.30 as %B cells), splenic tissue present on ultrasound (median, 122 mL), and no history of severe infection since SAE. In conclusion, this study quantitatively demonstrated that long-term immune function remains after SAE for blunt abdominal trauma based on the IgM memory B cell levels.
AB - Splenic artery embolization (SAE) plays a critical role in the treatment of high-grade splenic injury not requiring emergent laparotomy. SAE preserves splenic tissue, and growing evidence demonstrates preserved short-term splenic immune function after SAE. However, long-term function is less studied. Patients who underwent SAE for blunt abdominal trauma over a 10-year period were contacted for long-term follow-up. Sixteen participants (sex: women, 10, and men, 6; age: median, 34 years, and range, 18–67 years) were followed up at a median of 7.7 years (range, 4.7–12.8 years) after embolization. Splenic lacerations were of American Association for the Surgery of Trauma grades III to V, and 14 procedures involved proximal embolization. All individuals had measurable levels of IgM memory B cells (median, 14.30 as %B cells), splenic tissue present on ultrasound (median, 122 mL), and no history of severe infection since SAE. In conclusion, this study quantitatively demonstrated that long-term immune function remains after SAE for blunt abdominal trauma based on the IgM memory B cell levels.
UR - http://www.scopus.com/inward/record.url?scp=85129160260&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2022.02.004
DO - 10.1016/j.jvir.2022.02.004
M3 - Article
C2 - 35489783
AN - SCOPUS:85129160260
SN - 1051-0443
VL - 33
SP - 505
EP - 509
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 5
ER -