Immune consequences of kinase inhibitors in development, undergoing clinical trials and in current use in melanoma treatment

Laura J. Vella, Miles C. Andrews, Andreas Behren, Jonathan Cebon, Katherine Woods

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Metastatic malignant melanoma is a frequently fatal cancer. In recent years substantial therapeutic progress has occurred with the development of targeted kinase inhibitors and immunotherapeutics. Targeted therapies often result in rapid clinical benefit however responses are seldom durable. Immune therapies can result in durable disease control but responses may not be immediate. Optimal cancer therapy requires both rapid and durable cancer control and this can likely best be achieved by combining targeted therapies with immunotherapeutics. To achieve this, a detailed understanding of the immune consequences of the various kinase inhibitors, in development, clinical trial and currently used to treat melanoma is required.

Original languageEnglish
Pages (from-to)1107-1123
Number of pages17
JournalExpert Review of Clinical Immunology
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2014
Externally publishedYes

Keywords

  • Signaling

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