Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling

Yanhui Ma, Xiangliang Yuan, Lin Deng, Weiping Xu, Yingxia Zheng, Chaoyan Yue, Guanghui Zhang, Fang Xie, Yuan Hang Yang, Michael Paul Marie Gantier, Jun-Ping Liu, Dakang Xu, Lisong Shen

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17 Citations (Scopus)

Abstract

Extensive evidence suggests inflammatory components participate in the pathogenic processes of acute coronary syndromes (ACS). In this study, we aimed to elucidate the role and mechanism underlying the imbalance of Th17 and Treg cell peripheral populations in the pathogenesis of ACS. METHODS AND RESULTS: Using a flow cytometric analysis, we observed a significantly increased frequency of Th17 cells and a concurrently decreased CD4(+)CD25(+)Foxp3(+) Treg cells in patients with ACS. To elucidate the mechanism of Th17/Treg imbalance in ACS, 22 inflammatory cytokines were measured using multiplexed immunobead-based assays. Of six elevated cytokines in ACS patients, only IL-6 was positively correlated with a higher Th17 cell level (r = 0.39, P
Original languageEnglish
Pages (from-to)1 - 12
Number of pages12
JournalPLoS ONE
Volume8
Issue number8 (art. no. e72804)
DOIs
Publication statusPublished - 2013

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