MRI is increasingly gaining acceptance as a major tool for the diagnosis of human prion diseases, also known as transmissible spongiform encephalopathies (TSEs), which include Creutzfeldt–Jakob disease (sporadic, genetic, variant, and iatrogenic), fatal familial insomnia, and Gertsmann–Strausser–Sheinker syndrome. However, the rapid cognitive decline observed in many human TSEs makes performing MRI in these patients difficult. While CT and conventional MRI sequences (such as T1 and T2 weighted acquisitions) have limited diagnostic value, fluid attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI) have a very high specificity and relatively good sensitivity for the diagnosis of most TSEs. Research protocols may also include various other sequences such as magnetic resonance spectroscopy, diffusion tensor imaging, or functional MRI.
|Title of host publication||Imaging in Neurodegenerative Disorders|
|Place of Publication||Oxford UK|
|Publisher||Oxford University Press|
|Number of pages||9|
|Publication status||Published - 8 Jan 2015|