Image guidance and stabilization for stereotactic ablative body radiation therapy (SABR) treatment of primary kidney cancer

Daniel T Pham, Tomas Kron, Mathias Bressel, Farshad Foroudi, Nicholas Hardcastle, Michal E Schneider, Sally Soteriou, Jayson Innes, Shankar Siva

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4 Citations (Scopus)

Abstract

PURPOSE: Stereotactic ablative body radiation therapy for primary kidney cancer treatment relies on motion management that can quantify both the trajectory of kidney motion and stabilize the patient. A prospective ethics-approved clinical trial of stereotactic treatment to primary kidney targets was conducted at our institution. Our aim was to report on specific kidney tumor motion and the inter- and intrafraction motion as seen on treatment. METHODS AND MATERIALS: Patients with tumor size /=5 cm received 42 Gy in 3 fractions. All patients underwent a 4-dimensional computed tomography planning scan, immobilized in a dual-vacuum system. A conventional linear accelerator cone beam computed tomography scan was used for pre-, mid-, and posttreatment imaging to verify target position. RESULTS: Between July 2012 and October 2014, 33 targets from 32 consecutive patients (24 males/8 females) were treated. Seventeen targets were prescribed 26 Gy/1 fraction and the remaining 16 targets received 42 Gy/3 fractions. Kidney motion at each of the poles was not affected by the presence of tumor (P = .875), nor was the motion statistically different from the corresponding contralateral kidney pole (P = .909). The mean 3-dimensional displacement of the target at mid- and posttreatment was 1.3 mm (standard deviation +/- 1.6) and 1.0 mm (standard deviation +/- 1.3), respectively. The maximum displacement in any direction for 95 of the fractions at mid- and posttreatment was
Original languageEnglish
Pages (from-to)597 - 605
Number of pages9
JournalPractical Radiation Oncology
Volume5
Issue number6
DOIs
Publication statusPublished - 2015

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