IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

Anja Fröhlich, Benjamin J. Marsland, Ivo Sonderegger, Michael Kurrer, Martin R. Hodge, Nicola L. Harris, Manfred Kopf

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Interleukin 21 (IL-21) is a member of the common γ-chain family of cytokines, which influence a broad spectrum of immunologic responses. A number of studies have examined the function of IL-21, but its specific role in Th1/Th2-cell differentiation and related effector responses remains to be clarified. Thus, we generated IL-21R-deficient mice and have investigated the role of IL-21R signaling using a series of in vivo experimentally induced disease models. We first addressed the role of IL-21R signaling in Th2 immune responses by examining allergic airway inflammation, and Nippostrongylus brasiliensis and Heligmosomoides polygyrus antihelminth responses. In each of these systems, IL-21R signaling played a clear role in the development of Th2 responses. Comparatively, IL-21R signaling was not required for the containment of Leishmania major infection or the development of experimental autoimmune myocarditis, indicative of competent Th1 and Th17 responses, respectively. Adoptive transfer of T cells and analysis of IL-21R+/+/IL-21R -/- chimera mice revealed that IL-21R-signaling was central to Th2-cell survival or migration to peripheral tissues. Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses.

Original languageEnglish
Pages (from-to)2023-2031
Number of pages9
JournalBlood
Volume109
Issue number5
DOIs
Publication statusPublished - 1 Mar 2007
Externally publishedYes

Cite this

Fröhlich, Anja ; Marsland, Benjamin J. ; Sonderegger, Ivo ; Kurrer, Michael ; Hodge, Martin R. ; Harris, Nicola L. ; Kopf, Manfred. / IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. In: Blood. 2007 ; Vol. 109, No. 5. pp. 2023-2031.
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abstract = "Interleukin 21 (IL-21) is a member of the common γ-chain family of cytokines, which influence a broad spectrum of immunologic responses. A number of studies have examined the function of IL-21, but its specific role in Th1/Th2-cell differentiation and related effector responses remains to be clarified. Thus, we generated IL-21R-deficient mice and have investigated the role of IL-21R signaling using a series of in vivo experimentally induced disease models. We first addressed the role of IL-21R signaling in Th2 immune responses by examining allergic airway inflammation, and Nippostrongylus brasiliensis and Heligmosomoides polygyrus antihelminth responses. In each of these systems, IL-21R signaling played a clear role in the development of Th2 responses. Comparatively, IL-21R signaling was not required for the containment of Leishmania major infection or the development of experimental autoimmune myocarditis, indicative of competent Th1 and Th17 responses, respectively. Adoptive transfer of T cells and analysis of IL-21R+/+/IL-21R -/- chimera mice revealed that IL-21R-signaling was central to Th2-cell survival or migration to peripheral tissues. Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses.",
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IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. / Fröhlich, Anja; Marsland, Benjamin J.; Sonderegger, Ivo; Kurrer, Michael; Hodge, Martin R.; Harris, Nicola L.; Kopf, Manfred.

In: Blood, Vol. 109, No. 5, 01.03.2007, p. 2023-2031.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Fröhlich, Anja

AU - Marsland, Benjamin J.

AU - Sonderegger, Ivo

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AU - Harris, Nicola L.

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