Projects per year
Abstract
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8– CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.
Original language | English |
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Pages (from-to) | 1007-1016 |
Number of pages | 10 |
Journal | Cell Death and Differentiation |
Volume | 24 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2017 |
Projects
- 1 Finished
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Molecular and Cellular basis of inflammatory and immunodeficiency diseases
Mackay, C., Brink, R., Cook, M., Goodnow, C., Mackay-Fisson, F., Sprent, J., Tangye, S. & Vinuesa, C. G.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 31/12/16
Project: Research
Equipment
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Genome Modification Platform
Jeanette Rientjes (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility