IL-2 prevents deletion of developing T-regulatory cells in the thymus

Daniel Y. Hu, Rushika C Wirasinha, Christopher C. Goodnow, Stephen R Daley

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2 Citations (Scopus)

Abstract

In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8– CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.

Original languageEnglish
Pages (from-to)1007-1016
Number of pages10
JournalCell Death and Differentiation
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2017

Cite this

Hu, D. Y., Wirasinha, R. C., Goodnow, C. C., & Daley, S. R. (2017). IL-2 prevents deletion of developing T-regulatory cells in the thymus. Cell Death and Differentiation, 24(6), 1007-1016. https://doi.org/10.1038/cdd.2017.38