Projects per year
Abstract
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8– CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.
Original language | English |
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Pages (from-to) | 1007-1016 |
Number of pages | 10 |
Journal | Cell Death and Differentiation |
Volume | 24 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2017 |
Projects
- 1 Finished
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Molecular and Cellular basis of inflammatory and immunodeficiency diseases
Mackay, C. (Primary Chief Investigator (PCI)), Brink, R. (Chief Investigator (CI)), Cook, M. (Chief Investigator (CI)), Goodnow, C. (Chief Investigator (CI)), Mackay-Fisson, F. (Chief Investigator (CI)), Sprent, J. (Chief Investigator (CI)), Tangye, S. (Chief Investigator (CI)) & Vinuesa, C. G. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/12 → 31/12/16
Project: Research
Equipment
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Monash Genome Modification Platform (MGMP)
Rientjes, J. (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility