TY - JOUR
T1 - IL-2 mediates adjuvant effect of dendritic cells
AU - Granucci, Francesca
AU - Andrews, Daniel M.
AU - Degli-Esposti, Mariapia A.
AU - Ricciardi-Castagnoli, Paola
PY - 2002/4/1
Y1 - 2002/4/1
N2 - Research into the biology of dendritic cells (DCs) has shown that they play a central role in priming early and late immune responses. The recent finding that DCs produce interleukin-2 (IL-2) after microbial challenge suggests that this could be the mechanism by which DCs link innate and adaptive immunity. This hypothesis is supported also by the observation that murine cytomegalovirus, which is able to establish a persistent infection, can interfere with the ability of infected DCs to produce IL-2 and prime T cells.
AB - Research into the biology of dendritic cells (DCs) has shown that they play a central role in priming early and late immune responses. The recent finding that DCs produce interleukin-2 (IL-2) after microbial challenge suggests that this could be the mechanism by which DCs link innate and adaptive immunity. This hypothesis is supported also by the observation that murine cytomegalovirus, which is able to establish a persistent infection, can interfere with the ability of infected DCs to produce IL-2 and prime T cells.
UR - http://www.scopus.com/inward/record.url?scp=0036533642&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(02)02187-7
DO - 10.1016/S1471-4906(02)02187-7
M3 - Short Survey
C2 - 11923103
SN - 1471-4906
VL - 23
SP - 169
EP - 171
JO - Trends in Immunology
JF - Trends in Immunology
IS - 4
ER -