IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Lavanya Balakrishnan, Sowmya Soman, Yatish B Patil, Jayshree Advani, Joji K Thomas, Dattatraya V Desai, Urmila Kulkarni-Kale, H C Harsha, T S Keshava Prasad, Rajesh Raju, Akhilesh Pandey, Evdokia Dimitriadis, Aditi Chatterjee

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from NetPath , a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
Original languageEnglish
Pages (from-to)81 - 86
Number of pages6
JournalCell Communication and Adhesion
Volume20
Issue number3-4
DOIs
Publication statusPublished - 2013

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