IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

Mario M. Zaiss, Kendle M. Maslowski, Ilaria Mosconi, Nadine Guenat, Benjamin J. Marsland, Nicola L. Harris

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution between helminths and their mammalian hosts; however, the molecular mechanisms by which these organisms avert immune rejection are not clear. We have found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp) elicits the secretion of IL-1β in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminth chronicity. Indeed in mice deficient for IL-1β (IL-1β-/-), or treated with the soluble IL-1βR antagonist, Anakinra, helminth infection results in enhanced type 2 immunity and accelerated parasite expulsion. IL-1β acts to decrease production of IL-25 and IL-33 at early time points following infection and parasite rejection was determined to require IL-25. Taken together, these data indicate that Hp promotes the release of host-derived IL-1β that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity.

Original languageEnglish
Article numbere1003531
Number of pages15
JournalPLoS Pathogens
Volume9
Issue number8
DOIs
Publication statusPublished - 1 Aug 2013
Externally publishedYes

Cite this

Zaiss, Mario M. ; Maslowski, Kendle M. ; Mosconi, Ilaria ; Guenat, Nadine ; Marsland, Benjamin J. ; Harris, Nicola L. / IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity. In: PLoS Pathogens. 2013 ; Vol. 9, No. 8.
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IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity. / Zaiss, Mario M.; Maslowski, Kendle M.; Mosconi, Ilaria; Guenat, Nadine; Marsland, Benjamin J.; Harris, Nicola L.

In: PLoS Pathogens, Vol. 9, No. 8, e1003531, 01.08.2013.

Research output: Contribution to journalArticleResearchpeer-review

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