In Vivo Laser Confocal Microscopy Using the HRT-Rostock Cornea Module: Diversity and Diagnostic Implications in Patients with Uveitis

Lyndell L. Lim, Jing Xie, Chyn C. Chua, Tiffany Wong, Lani T. Hoang, Matthias D. Becker, Eric B. Suhler, James T. Rosenbaum, Friederike Mackensen

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


Purpose: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. Methods: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. Results: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without. Conclusions: Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.

Original languageEnglish
Pages (from-to)900-909
Number of pages10
JournalOcular Immunology and Inflammation
Issue number6
Publication statusPublished - 2018
Externally publishedYes


  • Confocal microscopy
  • imaging analysis
  • keratic precipitates
  • uveitis

Cite this