In vitro anti-proliferative and antioxidant activities of stem extracts of pereskia bleo (Kunth) DC (Cactaceae)

Hong Lim Lee, Hui Meng Er, Ammu Kutty Radhakrishnan

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6 Citations (Scopus)

Abstract

Pereskia bleo (Kunth) DC (Cactaceae) (Pereskia bleo) is a tropical plant that has been reported to possess cytotoxic acitivity against several human cancer cell lines. This study was carried out to investigate the in vitro anti-proliferative and antioxidant activities of the stem extracts of the plant. All extracts did not show significant anti-proliferative activity in both normal mouse fibroblast (NIH/3T3) and mouse mammary cancer (4T l) cell lines. There was an increased rate of proliferation when the 4T l cells were co-cultured with these extracts under certain conditions. Among the extracts, the t-butanol extract had the highest antioxidant property. All the extracts had the ability to protect normal mouse fibroblast cells against natural and oxidant-induced cell death by apoptosis.

Original languageEnglish
Pages (from-to)225-239
Number of pages15
JournalMalaysian Journal of Science
Volume28
Issue number3
DOIs
Publication statusPublished - 31 Dec 2009
Externally publishedYes

Keywords

  • Anti-proliferative
  • Antioxidant
  • Apoptosis
  • Oxidant-induced cell death
  • Pereskia bleo

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