IgG1 hypergammaglobulinaemia in chronic parasitic infections in mice: Evidence that the response reflects chronicity of antigen exposure

C. B. Chapman, P. M. Knopf, R. F. Anders, G. F. Mitchell

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The IgG1 molecules in the sera of IgG1 hypergammaglobulinaemic mice chronically infected with the larval cestode, Mesocestoides corti, are a heterogeneous population. Although antibodies to M. corti are present, the question of whether a minority or majority of the serum IgG1 molecules has anti-parasite reactivity remains open. The splenic PFC response to an intravenous injection of SRBC in M. corti-infected mice does not consist of an unusually high proportion of IgG1 anti-SRBC PFC. Moreover, the adoptive anti-DNP PFC response of spleen cells from M. corti-infected mice to DNP-M. corti is not biased towards IgG1 antibody production. Since IgG1 hypergammaglobulinaemia is seen in mice with chronic, 'high-dose' infections, an attempt has been made to simulate chronic antigenic exposure with SRBC in uninfected mice. A split, high'dose regime of SRBC injections leads to a high number and high proportion of IgG1 anti-SRBC PFC in the spleen in three strains of mice. The results suggest that the extra-ordinarily high levels of IgG1 seen in the sera of mice chronically infected with the metazoa, M. corti and Nematospiroides dubius, reflect persistent, high-dose, 'strong', T cell-dependent stimulation of the B cell system.

Original languageEnglish
Pages (from-to)389-400
Number of pages12
JournalAustralian Journal of Experimental Biology and Medical Science
Issue number4
Publication statusPublished - 1 Jan 1979
Externally publishedYes

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