Abstract
Global eradication of the human-infecting malaria parasite Plasmodium falciparum, the major cause of malaria mortality, is unlikely to be achieved without an effective vaccine. However, our limited understanding of how protective immune responses target malaria parasites in humans, and how to best elicit these immune responses through vaccination, has hampered vaccine development. The red blood cell invading stage of the parasite lifecycle (merozoite) displays antigens that are attractive vaccine candidates as they are accessible to antibodies and raise high antibody titres in naturally immune individuals. The number of merozoite antigens that elicit an immune response, and their structural and functional diversity, has led to a large number of lead antigens being pursued as vaccine candidates. Despite being seemingly spoilt for choice in terms of vaccine candidates, there is still a lack of consensus on exactly how merozoite antibodies reduce parasitemia and malaria disease. In this review we describe the various immune mechanisms that can result from IgG opsonization of merozoites, and highlight recent developments that support a role for these functional antibodies in naturally acquired and vaccine-induced immunity.
| Original language | English |
|---|---|
| Pages (from-to) | 585-595 |
| Number of pages | 11 |
| Journal | International Journal for Parasitology |
| Volume | 47 |
| Issue number | 10-11 |
| DOIs | |
| Publication status | Published - 1 Sep 2017 |
| Externally published | Yes |
Keywords
- Antibodies
- Immunity
- Malaria
- Merozoite
- Opsonisation
- Phagocytosis
Cite this
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IgG opsonization of merozoites : multiple immune mechanisms for malaria vaccine development. / Hill, Danika L.; Schofield, Louis; Wilson, Danny W.
In: International Journal for Parasitology, Vol. 47, No. 10-11, 01.09.2017, p. 585-595.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - IgG opsonization of merozoites
T2 - multiple immune mechanisms for malaria vaccine development
AU - Hill, Danika L.
AU - Schofield, Louis
AU - Wilson, Danny W.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Global eradication of the human-infecting malaria parasite Plasmodium falciparum, the major cause of malaria mortality, is unlikely to be achieved without an effective vaccine. However, our limited understanding of how protective immune responses target malaria parasites in humans, and how to best elicit these immune responses through vaccination, has hampered vaccine development. The red blood cell invading stage of the parasite lifecycle (merozoite) displays antigens that are attractive vaccine candidates as they are accessible to antibodies and raise high antibody titres in naturally immune individuals. The number of merozoite antigens that elicit an immune response, and their structural and functional diversity, has led to a large number of lead antigens being pursued as vaccine candidates. Despite being seemingly spoilt for choice in terms of vaccine candidates, there is still a lack of consensus on exactly how merozoite antibodies reduce parasitemia and malaria disease. In this review we describe the various immune mechanisms that can result from IgG opsonization of merozoites, and highlight recent developments that support a role for these functional antibodies in naturally acquired and vaccine-induced immunity.
AB - Global eradication of the human-infecting malaria parasite Plasmodium falciparum, the major cause of malaria mortality, is unlikely to be achieved without an effective vaccine. However, our limited understanding of how protective immune responses target malaria parasites in humans, and how to best elicit these immune responses through vaccination, has hampered vaccine development. The red blood cell invading stage of the parasite lifecycle (merozoite) displays antigens that are attractive vaccine candidates as they are accessible to antibodies and raise high antibody titres in naturally immune individuals. The number of merozoite antigens that elicit an immune response, and their structural and functional diversity, has led to a large number of lead antigens being pursued as vaccine candidates. Despite being seemingly spoilt for choice in terms of vaccine candidates, there is still a lack of consensus on exactly how merozoite antibodies reduce parasitemia and malaria disease. In this review we describe the various immune mechanisms that can result from IgG opsonization of merozoites, and highlight recent developments that support a role for these functional antibodies in naturally acquired and vaccine-induced immunity.
KW - Antibodies
KW - Immunity
KW - Malaria
KW - Merozoite
KW - Opsonisation
KW - Phagocytosis
UR - http://www.scopus.com/inward/record.url?scp=85021728619&partnerID=8YFLogxK
U2 - 10.1016/j.ijpara.2017.05.004
DO - 10.1016/j.ijpara.2017.05.004
M3 - Review Article
VL - 47
SP - 585
EP - 595
JO - International Journal for Parasitology
JF - International Journal for Parasitology
SN - 0020-7519
IS - 10-11
ER -