Abstract
Hypoxia stimulates tumor angiogenesis by inducing the expression of angiogenic molecules. The negative regulators of this
process, however, are not well understood. Here, we report that hypoxia induced the expression of insulin-like growth factor
binding protein-6 (IGFBP-6), a tumor repressor, in human and rodent vascular endothelial cells (VECs) via a hypoxia-inducible
factor (HIF)-mediated mechanism. Addition of human IGFBP-6 to cultured human VECs inhibited angiogenesis in vitro. An
IGFBP-6 mutant with at least 10,000-fold lower binding affinity for IGFs was an equally potent inhibitor of angiogenesis,
suggesting that this action of IGFBP-6 is IGF-independent....
Original language | English |
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Pages (from-to) | 2003 - 2012 |
Number of pages | 10 |
Journal | International Journal of Cancer |
Volume | 130 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2012 |