TY - JOUR
T1 - Garcinia mangostana peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats
AU - Abood, Walaa Najm
AU - Bradosty, Sarwan W.
AU - Shaikh, Faiyaz Khudaboddin
AU - Salehen, Nur'Ain
AU - Farghadani, Reyhaneh
AU - Agha, Nabaz Fisal Shakir
AU - Al-Medhtiy, Morteta H.
AU - Kamil, Treska Dhia Aldeen
AU - Agha, Ali Salim
AU - Abdulla, Mahmood Ameen
N1 - Funding Information:
The authors would like to thank the University of Malaya , Malaysia for providing grant funding to conduct this study.
Funding Information:
Funding statement: This study was financially supported by IPPP ( PG263-2015B ) and UMRG ( RPO43A15HTM ) grants from University of Malaya , Malaysia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 The Authors
PY - 2020/11
Y1 - 2020/11
N2 - The study in vivo evaluated the influence of ethanolic extract of G. mangostana peel on the histology, immunohistochemistry, and biochemistry of thioacetamide (TAA) induced liver cirrhosis in Sprague Drawly (SD) rats. The rats were distinctly administered with two doses of G. mangostana (250 mg/kg and 500 mg/kg) with TAA showed a significant reduction in liver index and hepatocyte proliferation with much lesser cell damage. These groups were significantly down-regulated the PCNA, α-SMA, and TGF-β1. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. Thus normal microanatomy of hepatocytes, suppression of PCNA, α-SMA, TGF-β, improved antioxidant enzymes, reduced MDA with restoration of liver biomarkers demonstrates hepatoprotective influence of G. mangostana.
AB - The study in vivo evaluated the influence of ethanolic extract of G. mangostana peel on the histology, immunohistochemistry, and biochemistry of thioacetamide (TAA) induced liver cirrhosis in Sprague Drawly (SD) rats. The rats were distinctly administered with two doses of G. mangostana (250 mg/kg and 500 mg/kg) with TAA showed a significant reduction in liver index and hepatocyte proliferation with much lesser cell damage. These groups were significantly down-regulated the PCNA, α-SMA, and TGF-β1. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. Thus normal microanatomy of hepatocytes, suppression of PCNA, α-SMA, TGF-β, improved antioxidant enzymes, reduced MDA with restoration of liver biomarkers demonstrates hepatoprotective influence of G. mangostana.
KW - Garcinia mangostana
KW - Hepatoprotective effect
KW - Liver cirrhosis
KW - Thioacetamide
KW - Traditional therapy
UR - http://www.scopus.com/inward/record.url?scp=85091260102&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2020.104200
DO - 10.1016/j.jff.2020.104200
M3 - Article
AN - SCOPUS:85091260102
SN - 1756-4646
VL - 74
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104200
ER -