IgA production without μ or δ chain expression in developing B cells

Andrew J.S. Macpherson, Alain Lamarre, Kathy McCoy, Gregory R. Harriman, Bernard Odermatt, Gordon Dougan, Hans Hengartner, Rolf M. Zinkernagel

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Abstract

Surface, membrane-bound, immunoglobulin M (IgM) or IgD expression early in B cell ontogeny is considered essential for the differentiation of antibody-producing cells in mammals; only in IgM+ B cells is the heavy chain locus rearranged to express antibodies of other classes. We show here that IgA is selectively expressed in μMT mice, which lack IgM or IgD expression and have a pro-B cell developmental block. μMT IgA binds proteins of commensal intestinal bacteria and is weakly induced by Salmonella infection, although not through conventional immunization. This μMT IgA pathway requires extrasplenic peripheral lymphoid tissues and may be an evolutionarily primitive system in which immature B cells switch to IgA production at peripheral sites.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalNature Immunology
Volume2
Issue number7
DOIs
Publication statusPublished - 6 Aug 2001
Externally publishedYes

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