IFN-γ-dependent recruitment of mature CD27high NK cells to lymph nodes primed by dendritic cells

Sally V. Watt, Daniel M. Andrews, Kazuyoshi Takeda, Mark J. Smyth, Yoshihiro Hayakawa

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59 Citations (Scopus)

Abstract

NK cells have been proposed to be an initial source of IFN-γ that supports either Th1 or CTL priming. Although NK cells reside in naive lymph nodes (LN) at a very low frequency, they can be recruited into LN draining sites of infection, inflammation, or immunization where they potentially influence adaptive immunity. In this study, we report that mature CD27high NK cells are predominantly recruited into the draining LN following dendritic cell (DC) challenge. Importantly, the recruitment of the CD27high NK cell subset in the draining LN was dependent on host IFN-γ and the activation status of NK cells. Endogenous epidermal DC migration induced by hapten challenge also triggers NK cell recruitment to the draining LN in an IFN-γ-dependent mechanism. Thus, our results identify that CD27 high NK cells are the dominant population recruited to the draining LN and NK cell recruitment requires endogenous IFN-γ in coordinating with DC migration.

Original languageEnglish
Pages (from-to)5323-5330
Number of pages8
JournalJournal of Immunology
Volume181
Issue number8
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes

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