Abstract
To delineate the roles of variant (vPRC1) and canonical (cPRC1) Polycomb repressive complex 1, Blackledge et al. (2020) and Tamburri et al. (2020) elegantly disrupt RING1A/B catalytic activity without affecting stability of either complex and then explore the precise contribution of vPRC1-mediated H2AK119ub1 to Polycomb-mediated gene repression.
Original language | English |
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Pages (from-to) | 685-687 |
Number of pages | 3 |
Journal | Molecular Cell |
Volume | 77 |
Issue number | 4 |
DOIs | |
Publication status | Published - 20 Feb 2020 |
Externally published | Yes |