Identifying the cognitive underpinnings of voice-hearing by comparing never, past and current voice-hearers

W. L. Toh, E. J. Tan, E. Neill, T. E. Van Rheenen, C. Gurvich, P. J. Sumner, S. P. Carruthers, E. H.X. Thomas, S. L. Rossell

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Objective: The current study aimed to compare specific cognitive profiles corresponding to auditory verbal hallucinations (AVH) status and elucidate which pattern of cognitive deficits may predict voice-hearing status. Method: Clinical participants with schizophrenia spectrum disorders were partitioned into: (i) current voice-hearers (n = 46), (ii) past voice-hearers (n = 37) and (iii) never voice-hearers (n = 40), and compared with 319 non-clinical controls. Cognitive assessment employed the MATRICS Consensus Cognitive Battery (MCCB), supplemented by the Delis–Kaplan Executive Function System (D-KEFS) Colour–Word Interference Test (Stroop) as a robust measure of executive function. Results: On the Visual Learning domain, current and past voice-hearers had significantly poorer performance relative to never voice-hearers, who in turn had significantly poorer performance than non-clinical controls. Current and never voice-hearers had significantly poorer performance on the Social Cognition domain relative to non-clinical controls. Current voice-hearers also had significantly poorer performance on the Inhibition domain relative to non-clinical controls. Binary logistic regression revealed that Visual Learning was the only significant cognitive predictor of AVH presence. Conclusion: Visual learning, and potentially inhibition, may be viable therapeutic targets when addressing cognitive mechanisms associated with AVHs. Future research should focus on investigating additional cognitive mechanisms, employing diverse voice-hearing populations and embarking on related longitudinal studies.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalActa Psychiatrica Scandinavica
Volume141
Issue number6
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • auditory verbal hallucinations
  • cognition
  • inhibition
  • psychosis
  • schizophrenia
  • visual learning

Cite this