Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis

Soi Cheng C Law, Helen Benham, Hugh H Reid, Jamie Rossjohn, Ranjeny Thomas

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9 Citations (Scopus)

Abstract

Despite treatment advances, rheumatoid arthritis (RA) is still associated with significant disability, decreased work capacity, and reduced life expectancy. Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to controlling and preventing RA. Design of effective therapies requires a fundamental understanding of the critical immunopathogenetic pathways in RA. This article reviews advances in the understanding of self-antigen-specific T cells in autoimmune diseases including RA and type 1 diabetes, which bring exciting insights to the mechanisms underpinning loss of tolerance and how tolerance could be restored for disease prevention in the preclinical or recent-onset period. © 2014 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)735 - 752
Number of pages18
JournalRheumatic Disease Clinics of North America
Volume40
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • HLA susceptibility
  • Immune tolerance
  • pMHC tetramers
  • Regulatory T cells
  • Rheumatoid arthritis
  • Type 1 diabetes

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