Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

Ashley S. Meakin; Janna L. Morrison; Emma L. Bradshaw; Stacey L. Holman; Zarqa Saif; Kathryn L. Gatford; Megan J. Wallace; Robert J. Bischof; Timothy J.M. Moss; Vicki L. Clifton

doi:10.1016/j.placenta.2021.01.003

Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

Ashley S. Meakin
, Janna L. Morrison
, Emma L. Bradshaw
, Stacey L. Holman
, Zarqa Saif
, Kathryn L. Gatford
, Megan J. Wallace
, Robert J. Bischof
, Timothy J.M. Moss
, Vicki L. Clifton

Obstetrics & Gynaecology Monash Health

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.

Original language	English
Pages (from-to)	232-235
Number of pages	4
Journal	Placenta
Volume	104
DOIs	https://doi.org/10.1016/j.placenta.2021.01.003
Publication status	Published - 15 Jan 2021

Keywords

Androgen receptor
Androgens
Asthma
Sheep

Access to Document

10.1016/j.placenta.2021.01.003

Cite this

@article{6d4f07b6f1454ff6b7653b4ce8559811,

title = "Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma",

abstract = "Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.",

keywords = "Androgen receptor, Androgens, Asthma, Sheep",

author = "Meakin, \{Ashley S.\} and Morrison, \{Janna L.\} and Bradshaw, \{Emma L.\} and Holman, \{Stacey L.\} and Zarqa Saif and Gatford, \{Kathryn L.\} and Wallace, \{Megan J.\} and Bischof, \{Robert J.\} and Moss, \{Timothy J.M.\} and Clifton, \{Vicki L.\}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = jan,

day = "15",

doi = "10.1016/j.placenta.2021.01.003",

language = "English",

volume = "104",

pages = "232--235",

journal = "Placenta",

issn = "1532-3102",

publisher = "Elsevier - WB Saunders",

}

TY - JOUR

T1 - Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

AU - Meakin, Ashley S.

AU - Morrison, Janna L.

AU - Bradshaw, Emma L.

AU - Holman, Stacey L.

AU - Saif, Zarqa

AU - Gatford, Kathryn L.

AU - Wallace, Megan J.

AU - Bischof, Robert J.

AU - Moss, Timothy J.M.

AU - Clifton, Vicki L.

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.

AB - Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.

KW - Androgen receptor

KW - Androgens

KW - Asthma

KW - Sheep

UR - https://www.scopus.com/pages/publications/85099247868

U2 - 10.1016/j.placenta.2021.01.003

DO - 10.1016/j.placenta.2021.01.003

M3 - Article

C2 - 33450642

AN - SCOPUS:85099247868

SN - 1532-3102

VL - 104

SP - 232

EP - 235

JO - Placenta

JF - Placenta

ER -

Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

Abstract

Keywords

Access to Document

Other files and links

Effect of maternal asthma and allergic challenge on maternal and fetal physiology

NHMRC Research Fellowship

Monash Animal Research Platform (MARP)

Cite this

Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

Abstract

Keywords

Access to Document

Other files and links

Projects

Effect of maternal asthma and allergic challenge on maternal and fetal physiology

NHMRC Research Fellowship

Equipment

Monash Animal Research Platform (MARP)

Cite this