Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Xiang Shu, Jirong Long, Qiuyin Cai, Sun Seog Kweon, Ji Yeob Choi, Michiaki Kubo, Sue K. Park, Manjeet K. Bolla, Joe Dennis, Qin Wang, Yaohua Yang, Jiajun Shi, Xingyi Guo, Bingshan Li, Ran Tao, Kristan J. Aronson, Kelvin Y.K. Chan, Tsun L. Chan, Yu Tang Gao, Mikael HartmanWeang Kee Ho, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Esther M. John, Yoshio Kasuga, Ui Soon Khoo, Mi Kyung Kim, Sun Young Kong, Allison W. Kurian, Ava Kwong, Eun Sook Lee, Jingmei Li, Artitaya Lophatananon, Siew Kee Low, Shivaani Mariapun, Koichi Matsuda, Keitaro Matsuo, Kenneth Muir, Dong Young Noh, Boyoung Park, Min Ho Park, Chen Yang Shen, Min Ho Shin, John J. Spinelli, Atsushi Takahashi, Chiuchen Tseng, Shoichiro Tsugane, Anna H. Wu, Yong Bing Xiang, Taiki Yamaji, Ying Zheng, Roger L. Milne, Alison M. Dunning, Paul D.P. Pharoah, Montserrat García-Closas, Soo Hwang Teo, Xiao ou Shu, Daehee Kang, Douglas F. Easton, Jacques Simard, Wei Zheng

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2 Citations (Scopus)

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

Original languageEnglish
Article number1217
Number of pages9
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020

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