Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development

Anthony Daniel Bird, Kheng Hui Tan, Fredrik Par Olsson, Malgorzata Zieba, Sharon Jayne Flecknoe, Douglas Liddicoat, Richard Anthony Mollard, Stuart Brian Hooper, Timothy James Cole

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Abstract

Glucocorticoids play a vital role in fetal respiratory development and act via the intracellular glucocorticoid receptor (GR) to regulate transcription of key target genes. GR-null mice die at birth due to respiratory dysfunction associated with hypercellularity and atelectasis. To identify events associated with this lung phenotype we examined perinatal cellular proliferation rates and apoptotic indices. We demonstrate that compared to wild type controls, day 18.5 post-coitum (p.c.) GR-null mouse lungs display significantly increased cell proliferation rates (1.8 fold p
Original languageEnglish
Pages (from-to)187 - 201
Number of pages15
JournalThe Journal of Physiology
Volume585
Issue number1
Publication statusPublished - 2007

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