TY - JOUR
T1 - Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development
AU - Bird, Anthony Daniel
AU - Tan, Kheng Hui
AU - Olsson, Fredrik Par
AU - Zieba, Malgorzata
AU - Flecknoe, Sharon Jayne
AU - Liddicoat, Douglas
AU - Mollard, Richard Anthony
AU - Hooper, Stuart Brian
AU - Cole, Timothy James
PY - 2007
Y1 - 2007
N2 - Glucocorticoids play a vital role in fetal respiratory development and act via the intracellular glucocorticoid receptor (GR) to regulate transcription of key target genes. GR-null mice die at birth due to respiratory dysfunction associated with hypercellularity and atelectasis. To identify events associated with this lung phenotype we examined perinatal cellular proliferation rates and apoptotic indices. We demonstrate that compared to wild type controls, day 18.5 post-coitum (p.c.) GR-null mouse lungs display significantly increased cell proliferation rates (1.8 fold p
AB - Glucocorticoids play a vital role in fetal respiratory development and act via the intracellular glucocorticoid receptor (GR) to regulate transcription of key target genes. GR-null mice die at birth due to respiratory dysfunction associated with hypercellularity and atelectasis. To identify events associated with this lung phenotype we examined perinatal cellular proliferation rates and apoptotic indices. We demonstrate that compared to wild type controls, day 18.5 post-coitum (p.c.) GR-null mouse lungs display significantly increased cell proliferation rates (1.8 fold p
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17901120
M3 - Article
SN - 0022-3751
VL - 585
SP - 187
EP - 201
JO - The Journal of Physiology
JF - The Journal of Physiology
IS - 1
ER -