Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

Astrid von Mentzer; Thomas R Connor; Lothar H. Wieler; Torsten Semmler; Atsushi Iguchi; Nicholas R Thomson; David A Rasko; Enrique Joffre; Jukka Corander; Derek Pickard; Gudrun Wiklund; Ann-Mari Svennerholm; Åsa Sjöling; Gordon Dougan

doi:10.1038/ng.3145

Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

Astrid von Mentzer, Thomas R Connor, Lothar H. Wieler, Torsten Semmler, Atsushi Iguchi, Nicholas R Thomson, David A Rasko, Enrique Joffre, Jukka Corander, Derek Pickard, Gudrun Wiklund, Ann-Mari Svennerholm, Åsa Sjöling, Gordon Dougan

Research output: Contribution to journal › Article › Research › peer-review

130 Citations (Scopus)

Abstract

Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.

Original language	English
Pages (from-to)	1321-1326
Number of pages	6
Journal	Nature Genetics
Volume	46
Issue number	12
DOIs	https://doi.org/10.1038/ng.3145
Publication status	Published - 10 Nov 2014
Externally published	Yes

Keywords

microbial genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.3145

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von Mentzer, A., Connor, T. R., Wieler, L. H., Semmler, T., Iguchi, A., Thomson, N. R., Rasko, D. A., Joffre, E., Corander, J., Pickard, D., Wiklund, G., Svennerholm, A-M., Sjöling, Å., & Dougan, G. (2014). Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution. Nature Genetics, 46(12), 1321-1326. https://doi.org/10.1038/ng.3145

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abstract = "Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.",

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AU - von Mentzer, Astrid

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AU - Semmler, Torsten

AU - Iguchi, Atsushi

AU - Thomson, Nicholas R

AU - Rasko, David A

AU - Joffre, Enrique

AU - Corander, Jukka

AU - Pickard, Derek

AU - Wiklund, Gudrun

AU - Svennerholm, Ann-Mari

AU - Sjöling, Åsa

AU - Dougan, Gordon

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AB - Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found across diverse E. coli serogroups. Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles. Contrary to current notions, these relatively recently emerged lineages might harbor chromosome and plasmid combinations that optimize fitness and transmissibility. These data have implications for understanding, tracking and possibly preventing ETEC disease.

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Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution

Abstract

Keywords

UN SDGs

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