Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2037 - 2045 |
| Number of pages | 9 |
| Journal | Journal of General Virology |
| Volume | 93 |
| Issue number | Pt 9 |
| DOIs | |
| Publication status | Published - 2012 |
Cite this
}
Identification of diverse groups of endogenous gammaretroviruses in mega and microbats. / Cui, Jie; Tachedjian, Gilda; Tachedjian, Mary; Holmes, Edward C; Zhang, Shuyi; Wang, Lin-Fa.
In: Journal of General Virology, Vol. 93, No. Pt 9, 2012, p. 2037 - 2045.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Identification of diverse groups of endogenous gammaretroviruses in mega and microbats
AU - Cui, Jie
AU - Tachedjian, Gilda
AU - Tachedjian, Mary
AU - Holmes, Edward C
AU - Zhang, Shuyi
AU - Wang, Lin-Fa
PY - 2012
Y1 - 2012
N2 - A previous phylogenetic study suggested that mammalian gammaretroviruses may have originated in bats. Here we report the discovery of RNA transcripts from two putative endogenous gammaretroviruses in frugivorous (Rousettus leschenaultii retrovirus, RlRV) and insectivorous (Megaderma lyra retrovirus, MlRV) bat species. Both genomes possess a large deletion in pol, indicating that they are defective retroviruses. Phylogenetic analysis places RlRV and MlRV within the diversity of mammalian gammaretroviruses, with the former falling closer to porcine endogenous retroviruses (PERVs) and the latter to Mus dunni endogenous virus (MDEV), koala retrovirus (KoRV), and gibbon ape leukemia virus (GALV). Additional genomic mining suggests that both microbat (Myotis lucifugus) and megabat (Pteropus vampyrus) genomes harbor many copies of endogenous retroviral forms related to RlRV and MlRV. Furthermore, phylogenetic analysis reveals the presence of three genetically diverse groups of endogenous gammaretroviruses in bat genomes, with M. lucifugus possessing members of all three groups. Taken together, this study indicates that bats harbor distinct gammaretroviruses and may have played an important role as reservoir hosts during the diversification of mammalian gammaretroviruses.
AB - A previous phylogenetic study suggested that mammalian gammaretroviruses may have originated in bats. Here we report the discovery of RNA transcripts from two putative endogenous gammaretroviruses in frugivorous (Rousettus leschenaultii retrovirus, RlRV) and insectivorous (Megaderma lyra retrovirus, MlRV) bat species. Both genomes possess a large deletion in pol, indicating that they are defective retroviruses. Phylogenetic analysis places RlRV and MlRV within the diversity of mammalian gammaretroviruses, with the former falling closer to porcine endogenous retroviruses (PERVs) and the latter to Mus dunni endogenous virus (MDEV), koala retrovirus (KoRV), and gibbon ape leukemia virus (GALV). Additional genomic mining suggests that both microbat (Myotis lucifugus) and megabat (Pteropus vampyrus) genomes harbor many copies of endogenous retroviral forms related to RlRV and MlRV. Furthermore, phylogenetic analysis reveals the presence of three genetically diverse groups of endogenous gammaretroviruses in bat genomes, with M. lucifugus possessing members of all three groups. Taken together, this study indicates that bats harbor distinct gammaretroviruses and may have played an important role as reservoir hosts during the diversification of mammalian gammaretroviruses.
UR - http://vir.sgmjournals.org/content/93/Pt_9/2037.full.pdf
U2 - 10.1099/vir.0.043760-0
DO - 10.1099/vir.0.043760-0
M3 - Article
VL - 93
SP - 2037
EP - 2045
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
IS - Pt 9
ER -