Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Hiroya Hasegawa, Takeshi Yamada, Naofumi Imai, Ichiei Narita, Hiroshi Kawachi, Kevan Polkinghorne, David Nikolic-Paterson, Makoto Uchiyama

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Abstract

New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.
Original languageEnglish
Pages (from-to)198 - 210
Number of pages13
JournalHistopathology
Volume58
Issue number2
DOIs
Publication statusPublished - 2011

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