Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

Yohei Ikezumi; Toshiaki Suzuki; Tamaki Karasawa; Hiroya Hasegawa; Takeshi Yamada; Naofumi Imai; Ichiei Narita; Hiroshi Kawachi; Kevan Polkinghorne; David Nikolic-Paterson; Makoto Uchiyama

doi:10.1111/j.1365-2559.2011.03742.x

Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Hiroya Hasegawa, Takeshi Yamada, Naofumi Imai, Ichiei Narita, Hiroshi Kawachi, Kevan Polkinghorne, David Nikolic-Paterson, Makoto Uchiyama

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

71 Citations (Scopus)

Abstract

New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.

Original language	English
Pages (from-to)	198 - 210
Number of pages	13
Journal	Histopathology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2559.2011.03742.x
Publication status	Published - 2011

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Ikezumi, Y., Suzuki, T., Karasawa, T., Hasegawa, H., Yamada, T., Imai, N., Narita, I., Kawachi, H., Polkinghorne, K., Nikolic-Paterson, D., & Uchiyama, M. (2011). Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion. Histopathology, 58(2), 198 - 210. https://doi.org/10.1111/j.1365-2559.2011.03742.x

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abstract = "New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.",

author = "Yohei Ikezumi and Toshiaki Suzuki and Tamaki Karasawa and Hiroya Hasegawa and Takeshi Yamada and Naofumi Imai and Ichiei Narita and Hiroshi Kawachi and Kevan Polkinghorne and David Nikolic-Paterson and Makoto Uchiyama",

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Ikezumi, Y, Suzuki, T, Karasawa, T, Hasegawa, H, Yamada, T, Imai, N, Narita, I, Kawachi, H, Polkinghorne, K , Nikolic-Paterson, D & Uchiyama, M 2011, 'Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion', Histopathology, vol. 58, no. 2, pp. 198 - 210. https://doi.org/10.1111/j.1365-2559.2011.03742.x

TY - JOUR

T1 - Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

AU - Ikezumi, Yohei

AU - Suzuki, Toshiaki

AU - Karasawa, Tamaki

AU - Hasegawa, Hiroya

AU - Yamada, Takeshi

AU - Imai, Naofumi

AU - Narita, Ichiei

AU - Kawachi, Hiroshi

AU - Polkinghorne, Kevan

AU - Nikolic-Paterson, David

AU - Uchiyama, Makoto

PY - 2011

Y1 - 2011

N2 - New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.

AB - New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.

UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.2011.03742.x/pdf

U2 - 10.1111/j.1365-2559.2011.03742.x

DO - 10.1111/j.1365-2559.2011.03742.x

M3 - Article

SN - 0309-0167

VL - 58

SP - 198

EP - 210

JO - Histopathology

JF - Histopathology

IS - 2

ER -

Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

Abstract

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