Abstract
New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.
Original language | English |
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Pages (from-to) | 198 - 210 |
Number of pages | 13 |
Journal | Histopathology |
Volume | 58 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 |