Identification of a splice variant of the rat estrogen receptor β gene

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Abstract

Recently a second estrogen receptor termed estrogen receptor β (ERβ) has been cloned and characterized, and shown to be expressed at the highest levels in ovarian granulosa cells and prostatic epithelium. In the course of amplifying a region of the ligand-binding domain of the rat ERβ cDNA we identified a second, larger transcript which appears to arise through differential splicing. The second isoform has 54 nucleotides inserted after position 1372 encoding 18 additional amino acids. Both isoforms are expressed at similar relative abundance in a range of tissues.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume132
Issue number1-2
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Estrogen
  • Isoforms
  • Ligand-binding domain
  • Steroid receptors

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