Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

Brad Sleebs, George Nikolakopoulos, Ian Philip Street, Hendrik Falk, Jonathan Bayldon Baell

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22 Citations (Scopus)


4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1.
Original languageEnglish
Pages (from-to)5992 - 5994
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 2011
Externally publishedYes

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