4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1.
Sleebs, B., Nikolakopoulos, G., Street, I. P., Falk, H., & Baell, J. B. (2011). Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorganic and Medicinal Chemistry Letters, 21(19), 5992 - 5994. https://doi.org/10.1016/j.bmcl.2011.07.050