Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J. Saunders, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E. Neal, Freddie C Hamdy, Jenny L. Donovan, Ken Muir, Graham G. Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A HaimanFredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J. Hunter, Susan M. Gapstur, Stephen J Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald L Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio B Riboli, Tim J. Key, Ruth C Travis, Daniele Campa, Sue A. Ingles, Esther M. John, Richard B Hayes, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford, Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y. Park, Radka P. Kaneva, Jyotsna Batra, Amanda B Spurdle, Judith A. Clements, Manuel R Teixeira, Ed Dicks, Andrew Lee, Alison M Dunning, Caroline Baynes, Don M. Conroy, Melanie J Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J. Sawyer, Angela Morgan, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S. Khoo, Christopher Parker, Nicholas J. Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S Cooper, Artitaya Lophatananon, Angela Cox, Melissa C. Southey, John L. Hopper, Dallas R. English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L. Zheng, Meredith Yeager, Rudolf J Kaaks, William Ryan Diver, Mia M Gaudet, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L.J. Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Sune F Nielsen, Stig E Bojesen, Afshan Siddiq, Liesel M. Fitzgerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, William J. Blot, Wei Zheng, Qiuyin Cai, Shannon K. McDonnell, Antje E. Rinckleb, Bettina Drake, Graham A Colditz, Dominika Wokolorczyk, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A Sellers, Hui-Yi Lin Lin, Chavdar Slavov, Vanio Mitev, Felicity A Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A. Cooney, Antonis C Antoniou, Daniel Vincent, François Bacot, Daniel C. Tessier, Zsofia Kote-Jarai, Douglas F Easton

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375 Citations (Scopus)

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalNature Genetics
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Cite this

Eeles, R. A., Al Olama, A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., Dadaev, T., Neal, D. E., Hamdy, F. C., Donovan, J. L., Muir, K., Giles, G. G., Severi, G., Wiklund, F., Gronberg, H., ... Easton, D. F. (2013). Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 45(4), 385-391. https://doi.org/10.1038/ng.2560