Identification and characterization of human endometrial mesenchymal stem/stromal cells and their potential for cellular therapy

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30 Citations (Scopus)

Abstract

Human endometrium is a highly regenerative tissue, under going more than 400 cycles of proliferation, differentiation, and shedding during a woman’s reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.

Original languageEnglish
Pages (from-to)1127-1132
Number of pages6
JournalStem Cells Translational Medicine
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 2016

Cite this

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title = "Identification and characterization of human endometrial mesenchymal stem/stromal cells and their potential for cellular therapy",
abstract = "Human endometrium is a highly regenerative tissue, under going more than 400 cycles of proliferation, differentiation, and shedding during a woman’s reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.",
author = "Saeedeh Darzi and Werkmeister, {Jerome A.} and Deane, {James A.} and Gargett, {Caroline E.}",
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T1 - Identification and characterization of human endometrial mesenchymal stem/stromal cells and their potential for cellular therapy

AU - Darzi, Saeedeh

AU - Werkmeister, Jerome A.

AU - Deane, James A.

AU - Gargett, Caroline E.

PY - 2016/9

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N2 - Human endometrium is a highly regenerative tissue, under going more than 400 cycles of proliferation, differentiation, and shedding during a woman’s reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.

AB - Human endometrium is a highly regenerative tissue, under going more than 400 cycles of proliferation, differentiation, and shedding during a woman’s reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.

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JO - Stem Cells Translational Medicine

JF - Stem Cells Translational Medicine

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