Identification and characterization of human endometrial mesenchymal stem/stromal cells and their potential for cellular therapy

Saeedeh Darzi, Jerome A. Werkmeister, James A. Deane, Caroline E. Gargett

Research output: Contribution to journalReview ArticleResearchpeer-review

51 Citations (Scopus)


Human endometrium is a highly regenerative tissue, under going more than 400 cycles of proliferation, differentiation, and shedding during a woman’s reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.

Original languageEnglish
Pages (from-to)1127-1132
Number of pages6
JournalStem Cells Translational Medicine
Issue number9
Publication statusPublished - Sep 2016

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