Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

Shakeel Mowlaboccus, Denise Daley, Stanley Pang, Thomas Gottlieb, John Merlino, Graeme R. Nimmo, Narelle George, Tony M. Korman, Richard Streitberg, Jenny Robson, Georgia Peachey, Peter Collignon, Susan Bradbury, Elena Colombi, Joshua P. Ramsay, Benjamin A. Rogers, Geoffrey W. Coombs

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Abstract

Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

Original languageEnglish
Article number106121
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume56
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Escherichia coli
  • fosA4
  • Fosfomycin resistance
  • Urinary tract infection

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