Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2

Mohamed Rajik, Fatemeh Jahanshiri, Abdul Rahman Omar, Aini Ideris, Sharifah Syed Hassan, Khatijah Yusoff

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    Abstract

    Avian influenza viruses (AIV) cause high morbidity and mortality among the poultry worldwide. Their highly mutative nature often results in the emergence of drug resistant strains, which have the potential of causing a pandemic. The virus has two immunologically important glycoproteins, hemagglutinin (HA), neuraminidase (NA), and one ion channel protein M2 which are the most important targets for drug discovery, on its surface. In order to identify a peptide-based virus inhibitor against any of these surface proteins, a disulfide constrained heptapeptide phage display library was biopanned against purified AIV sub-type H9N2 virus particles
    Original languageEnglish
    Pages (from-to)1 - 12
    Number of pages12
    JournalVirology Journal
    Volume6
    Issue number74
    DOIs
    Publication statusPublished - 2009

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