TY - JOUR
T1 - Campylobacter jejuni virulence factors
T2 - update on emerging issues and trends
AU - McNabb, Emmylee R.
AU - Petterlin, Luca
AU - Bellamy, Georgia L.
AU - Lin, Kyaw H.
AU - Santoso, Christopher A.
AU - Daye, Ella S.
AU - Alhaddad, Fatimah M.
AU - Lee, Kah Peng
A2 - Tikhomirova, Alexandra
A2 - Roujeinikova, Anna
N1 - Funding Information:
This work was supported by the National Health and Medical Research Council (NHMRC) Ideas grant 2011010 to A.R.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.
AB - Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.
KW - Biofilm
KW - Campylobacter jejuni
KW - Chemotaxis
KW - Pathogenesis
KW - Polysaccharide capsule
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85191695325&partnerID=8YFLogxK
U2 - 10.1186/s12929-024-01033-6
DO - 10.1186/s12929-024-01033-6
M3 - Review Article
C2 - 38693534
AN - SCOPUS:85191695325
SN - 1021-7770
VL - 31
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
IS - 1
M1 - 45
ER -
