Ia‐positive dendritic cells form a tightly meshed network within the human airway epithelium

P. G. HOLT; M. A. SCHON‐HEGRAD; M. J. PHILLIPS; P. G. MCMENAMIN

doi:10.1111/j.1365-2222.1989.tb02752.x

Ia‐positive dendritic cells form a tightly meshed network within the human airway epithelium

P. G. HOLT, M. A. SCHON‐HEGRAD, M. J. PHILLIPS, P. G. MCMENAMIN

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

In this report we have employed an alternative tissue‐sectioning procedure which provides a plan view of intra‐epithelial cell populations within the airway wall. Immunoperoxidase staining of such sections for class II MHC (Ia) antigen revealed the presence of a highly developed intra‐epithelial network of Ia‐positive dendritic cells, which was not evident employing conventional cross‐ or longitudinal tissue sections. This finding has important implications for the study of mechanisms underlying allergic and infectious diseases of the respiratory tract.

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	Clinical and Experimental Allergy
Volume	19
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2222.1989.tb02752.x
Publication status	Published - 1 Jan 1989
Externally published	Yes

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10.1111/j.1365-2222.1989.tb02752.x

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abstract = "In this report we have employed an alternative tissue‐sectioning procedure which provides a plan view of intra‐epithelial cell populations within the airway wall. Immunoperoxidase staining of such sections for class II MHC (Ia) antigen revealed the presence of a highly developed intra‐epithelial network of Ia‐positive dendritic cells, which was not evident employing conventional cross‐ or longitudinal tissue sections. This finding has important implications for the study of mechanisms underlying allergic and infectious diseases of the respiratory tract.",

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AB - In this report we have employed an alternative tissue‐sectioning procedure which provides a plan view of intra‐epithelial cell populations within the airway wall. Immunoperoxidase staining of such sections for class II MHC (Ia) antigen revealed the presence of a highly developed intra‐epithelial network of Ia‐positive dendritic cells, which was not evident employing conventional cross‐ or longitudinal tissue sections. This finding has important implications for the study of mechanisms underlying allergic and infectious diseases of the respiratory tract.

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Ia‐positive dendritic cells form a tightly meshed network within the human airway epithelium

Abstract

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