Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep

Guido Wassink; Robert D. Barrett; Joanne O. Davidson; Laura Bennet; Robert Galinsky; Michael Dragunow; Alistair J. Gunn

doi:10.1161/STROKEAHA.114.008484

Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep

Guido Wassink, Robert D. Barrett, Joanne O. Davidson, Laura Bennet, Robert Galinsky, Michael Dragunow, Alistair J. Gunn

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - : Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS - : 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS - : Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS - : Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.

Original language	English
Pages (from-to)	585-587
Number of pages	3
Journal	Stroke
Volume	46
Issue number	2
DOIs	https://doi.org/10.1161/STROKEAHA.114.008484
Publication status	Published - Feb 2015
Externally published	Yes

Keywords

EEG
hypothermia

Access to Document

10.1161/STROKEAHA.114.008484

243086908-oaFinal published version, 469 KB

Cite this

@article{f20f69df259b4554a1dee02b65616f73,

title = "Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep",

abstract = "BACKGROUND AND PURPOSE - : Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS - : 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS - : Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS - : Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.",

keywords = "EEG, hypothermia",

author = "Guido Wassink and Barrett, {Robert D.} and Davidson, {Joanne O.} and Laura Bennet and Robert Galinsky and Michael Dragunow and Gunn, {Alistair J.}",

year = "2015",

month = feb,

doi = "10.1161/STROKEAHA.114.008484",

language = "English",

volume = "46",

pages = "585--587",

journal = "Stroke",

issn = "0039-2499",

publisher = "American Heart Association",

number = "2",

}

TY - JOUR

T1 - Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep

AU - Wassink, Guido

AU - Barrett, Robert D.

AU - Davidson, Joanne O.

AU - Bennet, Laura

AU - Galinsky, Robert

AU - Dragunow, Michael

AU - Gunn, Alistair J.

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND AND PURPOSE - : Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS - : 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS - : Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS - : Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.

AB - BACKGROUND AND PURPOSE - : Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS - : 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS - : Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS - : Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.

KW - EEG

KW - hypothermia

UR - http://www.scopus.com/inward/record.url?scp=84922279914&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.114.008484

DO - 10.1161/STROKEAHA.114.008484

M3 - Article

C2 - 25586829

AN - SCOPUS:84922279914

SN - 0039-2499

VL - 46

SP - 585

EP - 587

JO - Stroke

JF - Stroke

IS - 2

ER -

Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep

Abstract

Keywords

Access to Document

Other files and links

Cite this