Hypothalamic-hypophyseal vascular connections in the fetal sheep

Mary L. Levidiotis, E. Marelyn Wintour, Brian J. Oldfield

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


We have studied the development of the hypothalamic-pituitary vascular connections in the fetal sheep using ink-filling techniques. The presence of ink-filled vessels in components of the hypothalamic-pituitary axis is interpreted as indicating patency of the system. Ink-filled vessels were identified in the median eminence, the pituitary stalk and the pituitary gland as early as 45 days of gestation and at all subsequent ages investigated. These results suggest that the pituitary could potentially respond to hypothalamic releasing factors from as early as 45 days of gestation in the fetal sheep.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
Issue number1
Publication statusPublished - 1 Jan 1989
Externally publishedYes


  • Fetal sheep
  • Ink filling
  • Median eminence
  • Pituitary
  • Vascular patency

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